This review was conducted using a systematic approach and keywords aimed at capturing the bulk of published research related to chiropractic care and immunity in humans. Given the limits related to key words and database searches, the search may not provide an exhaustive list of literature. The search was conducted between the dates of April 1, 2020 and April 6, 2020, using the databases Pubmed, Index to Chiropractic Literature, and CINAHL; key words searched were “immunity” and the following clinical care descriptors: chiropractic, osteopathic manipulation, spinal manipulation, spinal mobilization, and physical therapy manipulation. Additionally, the reference lists for each of the articles in the chiropractic and immunity reviews and the osteopathic and immunity reviews were searched for relevant articles, and some articles were added from the personal archive of Center for Chiropractic Research (CCR) investigators.
Please note that much of this literature provides a basic science perspective of changes in the body with chiropractic care. Basic science provides the basis for biological plausibility of a given intervention or approach. Biological plausibility describes the mechanisms and pathways associated with interventions of all kinds; it does not describe the effectiveness of a given intervention. Relative to chiropractic care and the immune system – including chiropractic and the current COVID-19 pandemic – there is still much to be done.